Saritha Krishna, PhD
Research Interests: Adult glioma, neuroplasticity, neurocogniton
My project focuses on synaptogenesis-mediated cortical plasticity in adult glioma patients. Some regions within gliomas have been found to have strong functional connectivity with surrounding brain areas and investigation of how the interface of this specific population of connectivity-rich glioma cells with their immediate vicinity neurons contribute to clinical recovery of language and cognitive deficits in brain tumor patients is the fundamental goal of my research.
2014: PhD, Physiology & Pharmacology, University of Georgia
Glioblastoma remodeling of neural circuits in the human brain decreases survival
Krishna S, Choudhury A, Keough M.B, Seo K, Ni L, Kakaizada S, Lee A, Aabedi A, Popova G, Lipkin B, Cao C, Gonzales C.N, Sudharshan R, Egladyous A, Ameida A, Zhang Y, Molinaro A.M, Venkatesh H.S, Daniel A.G.S, Shamardani K, Hyer J, Chang E.F, Findlay A, Phillips J.J, Nagarajan S, Raleigh D.R, Brang D, Monje M, and Hervey-Jumper S.
Nature. 2023; 617, 599–607.
Glioma-neuronal circuit remodeling induces regional immunosuppression
Nejo T, Krishna S, Jimenez C, Yamamichi A, Young J, Lakshmanachetty S, Chen T, Phyu S, Ogino H, Watchmaker P, Diebold D, Choudhury A, Daniel A, Raleigh D.R, Hervey-Jumper S, and Okada H.
Nature Communications. 2025; 16, 4770.
Gabapentinoids confer survival benefit in human glioblastoma
Bernstock J, Mehari M, Gerstl J, Meredith D, Valdes P, Heesen P, Ambati V, Krishna S, Chen J, Arora H, Johnston B, Negussie M, Pier Paolo Peruzzi R, Smith T, and Hervey-Jumper S.
Nature Communications. 2025; 16, 4483.
Malignant glioma remodeling of neuronal circuits: therapeutic opportunities and repurposing of antiepileptic drugs
Krishna S, Gonzales CN, Negussie NB, Ambati VS, and Hervey-Jumper S.
Trends in Cancer. 2024; 10 (12): 1106 – 1115.
Mechanisms of Cancer-Induced Remodeling of the Central Nervous System
Krishna S, Ambati V, and Hervey-Jumper SL.
In M. Amit & N. N. Scheff (Eds.), Cancer Neuroscience (pp. 35–48). Springer International Publishing.
Cancer-induced remodeling of the central nervous system
Krishna S and Hervey-Jumper S.
Advanced Biology special issue: Neuroregulation of Cancer. 2022; 6(9): e2200047.