visual graphic representing various tasks involved in brain mapping

Advances in Patient Specific Brain Mapping Strategies

The safe removal of many intrinsic brain tumors requires identifying brain regions that support critical cognitive and behavioral functions so care can be taken to preserve them during surgery.

Long-term existing neurological deficits can have a marked impact on survival. The current “gold standard” for pre-surgical mapping, electrocortical stimulation (ECS), provides a causal link between cortical regions and behavior.  ECS has been shown to identify function-critical cortical sites with high sensitivity and specificity however, its clinical effectiveness can be limited by prohibitively long acquisition time, reliance on overt responses from patients, and ambiguities regarding stimulation parameters and the interpretation of patient behavior. Our goal is to develop, validate, and clinically implement active ECS mapping strategies as well as passive electrocorticographical (ECoG) approaches to circumvents current limitations.


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Pekmezci M, Morshed RA, Chunduru P, Pandian B, Young J, Villanueva-Meyer JE, Tihan T, Sloan EA, Aghi MK, Molinaro AM, Berger MS, Hervey-Jumper SL. Detection of glioma infiltration at the tumor margin using quantitative stimulated Raman scattering histology. Sci Rep. 2021 Jun 9;11(1):12162. doi: 10.1038/s41598-021-91648-8. PMID: 34108566 

Aabedi AA, Kakaizada S, Young JS, Ahn E, Weissman DH, Berger MS, Brang D, Hervey-Jumper SL. Balancing task sensitivity with reliability for multimodal language assessments. J Neurosurg. 2021 May 28:1-8. doi: 10.3171/2020.10.JNS202947. Epub ahead of print. PMID: 34049284.

Muster RH, Young JS, Woo PYM, Morshed RA, Warrier G, Kakaizada S, Molinaro AM, Berger MS, Hervey-Jumper SL. The Relationship Between Stimulation Current and Functional Site Localization During Brain Mapping. Neurosurgery. 2021 May 13;88(6):1043-1050. doi: 10.1093/neuros/nyaa364. PMID: 33289525; PMCID: PMC8117445.

Hervey-Jumper SL, Berger MS. Evidence for Improving Outcome Through Extent of Resection. Neurosurg Clin N Am. 2019 Jan; 30(1):85-93. PMID: 30470408

Hervey-Jumper SL, Li J, Osorio JA, Lau D, Molinaro AM, Benet A, Berger MS. Surgical assessment of the insula. Part 2: validation of the Berger-Sanai zone classification system for predicting extent of glioma resection. J Neurosurg. 2016 Feb; 124(2):482-8. PMID: 26339856

Hervey-Jumper SL, Berger MS. Maximizing safe resection of low- and high-grade glioma. J Neurooncol 130(2): 269-282, 2016. PMID: 27174197

Hervey-Jumper SL, Berger MS. Technical nuances of awake brain tumor surgery and the role of maximum safe resection. J Neurosurg Sci. 2015 Dec; 59(4):351-60. PMID: 26394241

Hervey-Jumper SL, Li J, Lau D, Molinaro AM, Perry DW, Meng L, Berger MS. Awake craniotomy to maximize glioma resection: methods and technical nuances over a 27-year period. J Neurosurg. 2015 Aug; 123(2):325-39. PMID: 25909573