Interactions Between Gliomas and Functional Cognitive Networks
The vast majority glioma research is centered on survival, while little is known about the mechanisms by which gliomas affect functional cognitive networks.
There is preclinical evidence that neuronal activity influence glioma cell proliferation which is mediated in part by interactions between functioning neurons and glial cells. The brain-glioma relationship may be bi-directional and the study of this topic may contribute to our understanding of how gliomas infiltrate into cognitive neural networks. We therefore study the cellular underpinning behind why some glioma cells maintain functional connections with neurons and how maintaining these connections contributes to cognitive task performance.
Dr. Hervey-Jumper is also the director of the Glial Tumor Neuroscience Program, a coalition of interdisciplinary investigators dedicated to improving glioma therapies and treatments for post-acute survivorship.
Krishna S, Choudhury A, Keough MB, Seo K, Ni L, Kakaizada S, Lee A, Aabedi A, Popova G, Lipkin B, Cao C, Nava Gonzales C, Sudharshan R, Egladyous A, Almeida N, Zhang Y, Molinaro AM, Venkatesh HS, Daniel AGS, Shamardani K, Hyer J, Chang EF, Findlay A, Phillips JJ, Nagarajan S, Raleigh DR, Brang D, Monje M, Hervey-Jumper SL. Glioblastoma remodelling of human neural circuits decreases survival. Nature. 2023 May;617(7961):599-607. doi: 10.1038/s41586-023-06036-1. Epub 2023 May 3. PMID: 37138086; PMCID: PMC10191851.
Aabedi AA, Lipkin B, Kaur J, Kakaizada S, Valdivia C, Reihl S, Young JS, Lee AT, Krishna S, Berger MS, Chang EF, Brang D, Hervey-Jumper SL. Functional alterations in cortical processing of speech in glioma-infiltrated cortex. Proc Natl Acad Sci U S A. 2021 Nov 16;118(46):e2108959118. doi: 10.1073/pnas.2108959118. PMID: 34753819.
Aabedi AA, Kakaizada S, Young JS, Kaur J, Wiese O, Valdivia C, Krishna S, Weyer-Jamora C, Berger MS, Weissman DH, Brang D, Hervey-Jumper SL. Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex. Sci Rep. 2021 Mar 18;11(1):6305. doi: 10.1038/s41598-021-85802-5. PMID: 33737672.
Morshed RA, Young JS, Kroliczek AA, Berger MS, Brang D, Hervey-Jumper SL. A Neurosurgeon's Guide to Cognitive Dysfunction in Adult Glioma. Neurosurgery. 2021 Jun 15;89(1):1-10. doi: 10.1093/neuros/nyaa400. PMID: 33289504; PMCID: PMC8203420.
Weyer-Jamora C, Brie MS, Luks TL, Smith EM, Braunstein SE, Villanueva-Meyer JE, Bracci PM, Chang S, Hervey-Jumper SL, Taylor JW. Cognitive impact of lower-grade gliomas and strategies for rehabilitation. Neurooncol Pract. 2020 Nov 4;8(2):117-128. doi: 10.1093/nop/npaa072. PMID: 33898046; PMCID: PMC8049427.
Southwell DG*, Hervey-Jumper SL*, Perry DW, Berger MS. Intraoperative mapping during repeat awake craniotomy reveals the functional plasticity of adult cortex. J Neurosurg. 2016 May; 124(5):1460-9. PMID: 26544767 (*co-1st author)